Welcome to this awesome brand have video on outside his disease with the aid of some diagrams I'm going to describe the pathogenesis about Simon's resulting microscopic and macroscopic changes which take place and some of the clinical features which manifest with these changes. Sir what is awesome is disease Alzheimer's disease is a chronic nerve degenerative disease of the cortex which begins insidiously as impairment of high cognitive function and progresses resulting deficits of memory visuospatial orientation judgment personality and language these changes typically occur over a 5 to 10 year. First let's talk about the functioning of the house in your own in the part of the cell membrane of neurons which forms a sign ups there are numerous proteins called amyloid precursor proteins otherwise known as A. P. P. and as with all proteins old versions of a PPO degraded and new ones take their place 8 PP is normally broken down into soluble peptide spine enzyme called