On the right arc of the cycle, elevated stress exacerbates Alzheimer's Disease, causing more rapid development of pathology and loss in cognitive function. Researchers believe that a failure to properly build up reserves can result from an insufficient diet; however their results suggest that this may be due less often than previously believed. In particular they found significant effects on brain volume, which were most pronounced during periods where alcohol is consumed excessively. The mechanisms underlying neurodegeneration are not understood yet - but could involve immune modulation or increased levels for example of inflammatory mediators such as TNF-alpha or IL-6.
On the right arc of the cycle, elevated stress exacerbates Alzheimer's Disease, causing more rapid development of pathology and loss in cognitive function. This can accelerate with increasing age. Treatment by inhibiting AMP-activated protein kinase (AMPK) may prevent dementia progression as well: since some AD patients develop toxic amyloid plaques from an early diagnosis, treatment studies are focusing on developing strategies to slow down or stop such mutations before the disease starts. Further research is needed into how this work might apply to other molecular models for diseases like Parkinsonism; also looking at ways drug treatments could influence brain activity after drugs have been applied elsewhere,. There does seem a strong association between aging, PD, and neurodeg.
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