Time is deceased was described for the first time in 1907 by the German psychiatrist Eloise as a timer. In performing histopathologic studies of the brain of his patient Augustine suffering from dementia he brought to light the presence of 2 types of lesions in the brain. Senile plaques and neurofibrillary tangles he reached the conclusion of a distinct disease of a cerebral cortex 100 years later, thanks to current scientific techniques research has made a great leap and the understanding of the disease. We know that the brain is made up of neurons and that these are interconnected to form a vast network. These connections known as synapses enable the transmission of information from one neuron to another. And now it's time for us to cease 10 to 15 years before the appearance of the symptoms to main lesions forms in the brain. Senile plaques composed of amyloid-beta protein and neurofibrillary tangles composed of tau protein. How is the senile plaque formed? On the surfa