Alzheimer's Disease

  Time is deceased was described for the first time in 1907 by the German psychiatrist Eloise as a timer.  In performing histopathologic studies of the brain of his patient Augustine suffering from dementia he brought to light the presence of 2 types of lesions in the brain.  Senile plaques and neurofibrillary tangles he reached the conclusion of a distinct disease of a cerebral cortex 100 years later, thanks to current scientific techniques research has made a great leap and the understanding of the disease.  We know that the brain is made up of neurons and that these are interconnected to form a vast network.  These connections known as synapses enable the transmission of information from one neuron to another.  And now it's time for us to cease 10 to 15 years before the appearance of the symptoms to main lesions forms in the brain.  Senile plaques composed of amyloid-beta protein and neurofibrillary tangles composed of tau protein.  How is the senile plaque formed?  On the surfa

 With the growth of age, disease comes gradually and some of them become dominant. Family history and lifestyle are important.  This is a genetic condition that most often occurs after an accident or trauma to the head, especially when someone has died from this type of stroke. This can also happen if you are pregnant or suffering from traumatic damage such as your baby's birth.  The symptoms can include difficulty seeing, hearing, or thinking clearly, along with involuntary muscle spasms and mental confusion. 

  Lipid peroxidation consists of the hydroxy radical attack of unsaturated lipids to generate highly reactive secondary products such as reactive carbonyls and reactive aldehydes, which are able to inactivate enzyme active sites overriding their physiological role. Furthermore, oxidized membranes have altered mobility. Aldehyde adducts of protein are common on senile plaques and neurofibrillary tangles and are most prominent in cell bodies of vulnerable neurons.  When proteins are oxidized, the peptide bond could be compromised and it can be cleaved. Moreover, reactive carbonyls are frequently generated and also protein nitration, a related phenomenon. All these protein modifications happen prominently in neuronal cell bodies. Lastly, nucleic acids could also be affected by oxidation. ROS can alter both purinic and pyrimidinic bases with mutagenic and even deleterious results. Vulnerable neuronal cell bodies accumulate ostensibly oxidized nucleic acids. Consequently, it is not surpris

Time is deceased was described for the first time in 1907 by the German psychiatrist Eloise as a timer.  In performing a histopathologic studies of the brain of his patient Augustine suffering from dementia he brought to light the presence of 2 types of lesions in the brain.  Senile plaques and neurofibrillary tangles he reached the conclusion of a distinct disease of a cerebral cortex 100 years later thanks to current scientific techniques research has made a great leap and the understanding of the disease.  We know that the brain is made up of neurons and that these are interconnected to form a vast network.  These connections known as synapses enable the transmission of information from one neuron to another.  And now it's time for us to cease 10 to 15 years before the appearance of the symptoms to main lesions form in the brain.  Senile plaques composed of amyloid beta protein and neurofibrillary tangles composed of tau protein.  How is the senile plaque formed.  On the surface