Skip to main content

Posts

Lipid peroxidation

 Lipid peroxidation (PPO) is a process by which fatty acids are converted into lipid derivatives, such as ceramide and apigenin. The breakdown of PPOs results in their formation of short-chain metabolites including butyrate, propionyl-alpha hydroxybutyrate/proline acetate, and diacylglycerol derived from glucose. To maintain the production levels necessary for healthy blood lipids it is important to obtain adequate quantities daily with sufficient carbohydrate intake within these amounts on an individual basis. Consequently increasing dietary fat leads not only directly toward hypertriglyceridemia metabolism but also increases hepatic secretion throughout the entire body.

Researchers thought AD was an age-related

 In the past, researchers thought AD was an age-related disorder. However, there's been little research on whether it affects children as well. "We did have a small study from 2002 where they were using older people in nursing homes," said Schaeffer of Vanderbilt University, which involved comparing blood samples between six elderly patients and eight younger healthy volunteers over 10 years. In that work, scientists looked at DNA methylation patterns along with clinical features such as changes to cortisol levels during cognitive performance tests. The idea is that memory impairments should be caused by abnormal protein activity rather than altered neuronal pathways when cells are being activated - or silenced.  However now scientists are beginning a review of the evidence supporting this notion and suggesting that there may actually BE "aging" symptoms like dementia among young adults regardless if these can be explained by Alzheimer's disease or other men

Oxidized nucleic acids

  Lipid peroxidation consists of the hydroxy radical attack of unsaturated lipids to generate highly reactive secondary products such as reactive carbonyls and reactive aldehydes, which are able to inactivate enzyme active sites overriding their physiological role. Furthermore, oxidized membranes have altered mobility. Aldehyde adducts of protein are common on senile plaques and neurofibrillary tangles and are most prominent in cell bodies of vulnerable neurons.  When proteins are oxidized, the peptide bond could be compromised and it can be cleaved. Moreover, reactive carbonyls are frequently generated and also protein nitration, a related phenomenon. All these protein modifications happen prominently in neuronal cell bodies. Lastly, nucleic acids could also be affected by oxidation. ROS can alter both purinic and pyrimidinic bases with mutagenic and even deleterious results. Vulnerable neuronal cell bodies accumulate ostensibly oxidized nucleic acids. Consequently, it is not surpris

Alzheimer’s disease (AD)

 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a long evolution whose clinical symptoms appear late in life. However, in the last years, the paradigm of AD has changed. In the past, researchers thought AD was an age-related disorder that begins during the aging process. Today we know that the onset of the disease occurs between 15 (for the genetic) and 20–30 years (for the sporadic) before any clinical symptom appears.  There is no preventive or curative therapy for the disease and the lack of knowledge of when the disease begins greatly complicates the work of the physicians. Another added handicap is that neither do we know why the disease begins. In this sense, there are several hypotheses trying to explain the beginning of AD. These hypotheses may not be exclusive, and they may well overlap and take place at the same time. We can divide the hypotheses into three groups: The hypotheses based on protein deposits. This group includes the beta-amyloid (Aβ)

Vitamin E is an antioxidant

 Vitamin E was proposed as a treatment for Alzheimer’s disease many years ago. However, the effectiveness of the drug is not clear. Vitamin E is an antioxidant and neuroprotector and it has anti-inflammatory and hypocholesterolemic properties, driving to its importance for brain health. Moreover, the levels of vitamin E in Alzheimer’s disease patients are lower than in non-demented controls. Thus, vitamin E could be a good candidate to have beneficial effects against Alzheimer’s. However, evidence is consistent with a limited effectiveness of vitamin E in slowing progression of dementia; the information is mixed and inconclusive. The question is why does vitamin E fail to treat Alzheimer’s disease? In this paper we review the studies with and without positive results in Alzheimer’s disease and we discuss the reasons why vitamin E as treatment sometimes has positive results on cognition.

Alzheimer's disease in Germany

 In Germany, more than 1.5 million people are living with Alzheimer's disease. Worldwide, at least 44 million people are living with dementia, making the disease a global health crisis that must be addressed.  Alzheimer's disease. Worldwide, at least 44 million people are living with dementia, making the disease a global health crisis that must be addressed.  Tobacco use is now associated in some studies and literature with higher risks of developing cognitive disorders like mild cognitive impairment, which can lead not only directly but also indirectly through damage on future generations' mental capacities. The problem for governments facing this challenge has been how do you raise awareness about these harmful habits while ensuring effective harm reduction? For example there is relatively little public knowledge surrounding smoking during pregnancy (which helps explain why early women don't smoke as much), or around weight loss interventions such it diets. These effo

Alzheimer's in India

 Alzheimer's in India is not uncommon. Dementia is a disorder of the brain affecting memory and language skills in elderly people. Alzheimer's Disease is the most common type of Dementia and about 5-6% of people in the age group of 65-70 years in India suffer from this problem. The disease progresses rapidly with time (like dementia) because it does not have an end-stage which means that symptoms become more acute over time. People who develop dementia during old age are also vulnerable to health problems such as cardiovascular, eye ailments or respiratory diseases. This was recognized by the Indian government before independence but its progress has been slow.